Datananas allows you to synchronize your email address.
This will allow you to program your emails from Datananas, you will find them in your outbox. When a prospect answers you, he will be automatically removed from the current sequence and the next scheduled emails will be cancelled.
To synchronize your email address you have different options depending on your provider and configuration. Here is the list of available methods and a link to the dedicated article:
Synchronization Gmail / Gsuite
Synchronization Exchange / Outlook
Synchronization SMTP / IMAP
Warning: Be careful not to synchronize an email address representing an alias or a redirection because the reply emails from your prospects will not go back to your Datananas inbox and their sequence state will not evolve if they reply to your sequence.